O tratamento da leucoencefalopatia multifocal progressiva é principalmente de suporte. O uso experimental de fármacos como cidofovir e outros antivirais não mostrou benefício.
What is the epidemiology of multifocal leukoencephalopathy?
Epidemiology. Progressive multifocal leukoencephalopathy is strongly associated with immunosuppressed states, and primary PML developing in an immunocompetent patient is very rare. Classically, PML occurred in patients with AIDS, typically developing in patients with CD4 counts of 50-100 cells/μL, and is found in approximately 5% of autopsies
What are the signs and symptoms of progressive multifocal leukoencephalopathy?
Patients with progressive multifocal leukoencephalopathy present with various neurological symptoms. It typically spares the optic nerve and the spinal cord. The most frequently encountered symptoms include: altered mental status. motor deficits. limb and gait ataxia. visual symptoms (diplopia and hemianopia)
Does PD-1 play a role in progressive multifocal leukoencephalopathy?
Background: Progressive multifocal leukoencephalopathy (PML) is an opportunistic brain infection that is caused by the JC virus and is typically fatal unless immune function can be restored. Programmed cell death protein 1 (PD-1) is a negative regulator of the immune response that may contribute to impaired viral clearance.