The H. pylori genotype, host gene polymorphisms, and environmental factors determine the type of induced disease. Currently, the most common therapy to treat H. pylori is the first line clarithromycin-based triple therapy or a quadruple therapy replacing clarithromycin with new antibiotics.
How effective are antibiotic regimens for Helicobacter pylori treatment?
Multiple antibiotic regimens have been evaluated for Helicobacter pylori ( H. pylori) therapy. However, few regimens have consistently achieved high eradication rates. There are also limited data on H. pylori antibiotic resistance rates to guide therapy.
What is the ACG treatment guideline for Helicobacter pylori (HP)?
The ACG treatment guideline for first-line and salvage therapies was last updated in 2017. Typically, H pylori is treated with 2 to 3 antibiotics and a PPI. 7 The 2017 ACG guideline outlines evidence-based, frontline treatment strategies for providers in North America.
What is Helicobacter pylori (HP) infection?
Helicobacter pylori (H. pylori) infection is a common worldwide infection that is an important cause of peptic ulcer disease and gastric cancer.
When is clarithromycin triple therapy indicated for the treatment of Helicobacter pylori infection?
For first-line treatment, clarithromycin triple therapy should be confined to patients with no previous history of macrolide exposure who reside in areas where clarithromycin resistance amongst H. pylori isolates is known to be low.